Test Performed by:

HAZLETON LABORATORIES AMERICA, INC.

9200 Leesburg Turnpike

Vienna, Virginia 22180, U.S.A.








ACUTE ORAL TOXICITY STUDY
IN RATS


 

INSPECTA-SHIELD®


 

FINAL REPORT


 

 

 

 

 

 

 

 

 

 

 

 

 

Submitted to:

 

N.Y. Fire-Shield, Inc.

Auburn, NY

 

March 12, 1987

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



SAMPLE NUMBER:  70300024


Inspecta-Shield®, a yellow liquid, received on January 7, 1987, and stored at room temperature.

 

ACUTE ORAL TOXICITY STUDY IN RATS

 

Project Number:  2466-100

 

SUMMARY

 

Test Animal:  Albino Rats – Crl: CD  (SD) BR strain

Source:  Charles River Laboratories, Inc., Kingston, New York

 

Vehicle:   Distilled Water

 

Date Animals Received:  January 14, 1987

Date Test Started:  January 30, 1987

Date Test Completed:  February 13, 1987

 

Method of Administration:  Gavage

Estimated Oral LD50:  Male – Greater than 5000 mg/kg of body weight

Female – Greater than 5000 mg/kg of body weight



Animal INDIVIDUAL BODY WEIGHTS (g) BODY WEIGHT CHANGE
Number Initial Day 7 Terminal   Initiation-Termination
Males - 500 mg/kg
DO4346 264.6 313.8 350.2   85.6
DO4347 263.7 317.4 344.6   80.9
DO4348 263.4 319.1 354.8   91.4
DO4349 275.6 322.3 358.1   82.5
DO4350 267.8 328.9 355.4   87.6
Females - 500 mg/kg
DO4420 243.7 269.3 280.1   36.4
DO4421 251.6 277.4 293.0   41.4
DO4422 237.1 266.3 273.7   33.4
DO4423 239.7 261.2 273.1   33.4
DO4424 233.8 260.9 268.7   34.9






SAMPLE NUMBER:   70300024



Inspecta-Shield®, a yellow liquid, received on January 7, 1987, and stored at room temperature.



ACUTE ORAL TOXICITY STUDY IN RATS                         (CONTINUED)

OBSERVATION HOURS   DAYS
  1 2 4   1 2 3 4 5 6 7 8 9 10 11 12 13 14
Males - 5000 mg/kg
No. of animals 5 5 5   5 5 5 5 5 5 5 5 5 5 5 5 5 5
Normal 5 5 5   5 5 5 5 5 5 5 5 5 5 5 5 5 5
Females - 500 mg/kg
No. of animals 5 5 5   5 5 5 5 5 5 5 5 5 5 5 5 5 5
Normal 5 5 5   5 5 5 5 5 5 5 5 5 5 5 5 5 5



All animals survived, gained weight, and appeared normal from initiation to termination. No observable gross pathology findings were noted in any of the animas at the time of necropsy. Based upon the results of this study, the acute oral LD50 was estimated to be greater than 5000 mg/kg of body weight in male, female, and combined male and female rats.


*For a full copy of this report please contact us.