Test Performed by:

HAZLETON LABORATORIES AMERICA, INC.

9200 Leesburg Turnpike

Vienna, Virginia 22180, U.S.A.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Submitted to:

 

N.Y. Fire-Shield, Inc.

Auburn, NY

 

March 12, 1987

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

SAMPLE NUMBER:  70300024

 

Inspecta-Shield®, a yellow liquid, received on January 7, 1987,

and stored at room temperature.

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            ACUTE ORAL TOXICITY STUDY IN RATS

 

                    Project Number:  2466-100

 

SUMMARY

 

 

                    Test Animal:  Albino Rats – Crl: CD  (SD) BR strain

                    Source:  Charles River Laboratories, Inc., Kingston, New York

 

                    Vehicle:   Distilled Water

 

                    Date Animals Received:  January 14, 1987

                    Date Test Started:  January 30, 1987

                    Date Test Completed:  February 13, 1987

 

                    Method of Administration:  Gavage

                    Estimated Oral LD50:  Male – Greater than 5000 mg/kg of body weight

                                                            Female – Greater than 5000 mg/kg of body weight

 

Animal            INDIVIDUAL BODY WEIGHTS (g)          BODY WEIGHT CHANGE

Number             Initial              Day 7          Terminal                   Initiation-Termination      

 

Males – 5000 mg/kg

 

DO4346            264.6                 313.8         350.2                                85.6

DO4347            263.7                 317.4         344.6                                80.9

DO4348            263.4                 319.1         354.8                                91.4

DO4349            275.6                 322.3         358.1                                82.5

DO4350            267.8                 328.9         355.4                                87.6

 

Females – 5000 mg/kg

 

DO4420            243.7                 269.3         280.1                                36.4

DO4421            251.6                 277.4         293.0                                41.4

DO4422            237.1                 266.3         273.7                                33.4

DO4423            239.7                 261.2         273.1                                33.4

DO4424            233.8                 260.9         268.7                                34.9

 

 

 

SAMPLE NUMBER:   70300024

 

 

Inspecta-Shield®, a yellow liquid, received on January 7, 1987, and stored at room temperature.

 

 

ACUTE ORAL TOXICITY STUDY IN RATS                         (CONTINUED)

 

 

                                                _______________CLINICAL OBSERVATIONS_____________________

            OBSERVATION          __HOURS__     ___________________DAYS________________________

                                                 1      2      4          1    2     3    4    5    6    7    8    9    10    11    12    13    14           

 

Males – 5000 mg/kg

 

            No. of animals              5      5      5          5    5    5    5    5   5    5    5   5    5      5      5      5      5

            Normal                          5      5      5          5    5    5    5    5   5    5    5   5    5      5      5      5      5

 

 

Females – 5000 mg/kg

 

 

            No. of animals              5      5      5          5    5    5    5    5   5    5    5   5    5      5      5      5      5

            Normal                          5      5      5          5    5    5    5    5   5    5    5   5    5      5      5      5      5

 

 

 

 

All animals survived, gained weight, and appeared normal from initiation to termination. No observable gross pathology findings were noted in any of the animas at the time of necropsy. Based upon the results of this study, the acute oral LD50 was estimated to be greater than 5000 mg/kg of body weight in male, female, and combined male and female rats.

 

 

 

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